178 E6AP Ubiquitin Ligase Regulates PML-induced Senescence in Myc-driven Lymphomagenesis
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چکیده
منابع مشابه
E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis.
Neoplastic transformation requires the elimination of key tumor suppressors, which may result from E3 ligase-mediated proteasomal degradation. We previously demonstrated a key role for the E3 ubiquitin ligase E6AP in the regulation of promyelocytic leukemia protein (PML) stability and formation of PML nuclear bodies. Here, we report the involvement of the E6AP-PML axis in B-cell lymphoma develo...
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1Research Division, The Peter MacCallum Cancer Centre, East Melbourne, Australia; 2Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia; 3Department of Clinical Haematology, Monash Medical Centre, Clayton, Australia; 4Memorial Sloan-Kettering Cancer Center, New York, NY; 5The Hebrew University Hadassah Medical School, Jerusalem, Israel; 6Department of An...
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CCAAT/Enhancer Binding Protein Alpha (C/EBPα) is a key transcription factor involved in the adipocyte differentiation. Here for the first time we demonstrate that E6AP, an E3 ubiquitin ligase inhibits adipocyte differentiation in 3T3-L1 cells as revealed by reduced lipid staining with oil red. Knock down of E6AP in mouse 3T3L1 preadipocytes is sufficient to convert them to adipocytes independen...
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High-risk human papilloma viruses are known to be associated with cervical cancers. We have reported previously that the high-risk human papillomavirus (HPV) E6 oncoprotein interacts with E6TP1, a novel Rap GTPase-activating protein (RapGAP). Similar to p53 tumor suppressor protein, the high-risk HPV E6 oncoproteins target E6TP1 for degradation. The HPV16 E6-induced degradation of E6TP1 strongl...
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ژورنال
عنوان ژورنال: European Journal of Cancer
سال: 2012
ISSN: 0959-8049
DOI: 10.1016/s0959-8049(12)70877-8